Pathophysiology and Pathogenesis of COPD
The pathogenesis of COPD is that constant airflow restriction. Airspace inflammation appears to be diverse in vulnerable smokers and Chronic Inflammation includes a power of breathed in aggravations, for example, CD8+ T lymphocytes, neutrophils, and macrophages, B cells and macrophages together when activated, these cells start a inflammatory cascade(tumor necrosis factor alpha) and prompts to structural changes. Airway rebuilding in COPD is an immediate consequence of the inflammatory response related with COPD and resulting in the narrowing of the airways. Chronic Inflammation may also be added by bacterial infection.
The diseases that includes under the COPD are: Chronic Bronchitis, Emphysema and COPD-Asthma overlap. Bronchitis causes inflammation and irritation of the airways in the lungs. Over time, this mucus plugs up airways and makes breathing difficult. Emphysema is a common type of COPD in which the lung’s air sacs become damaged and destroyed. This damaged area makes difficulty for the people with emphysema to expel air from their lungs. Asthma COPD Overlap Syndrome (ACOS) usually includes increased reversibility of airflow obstruction, systemic inflammation and eosinophilic bronchial
· Pathology of Smoking
· Chronic Pulmonary Hypertension
· Chronic Pulmonary RehabilitationAlpha-1 antitrypsin(AAT) deficiency